The following Profile functionality is available in Zend Studio:
Locally Profiling a PHP Script - Profile a PHP Script using Zend Studio's internal debugger
Profiling a PHP Web Page - Profile PHP files on a remote server
Profiling a URL - Profile a URL
Once a Profile session has been launched, the PHP Profile perspective is used to view and analyze the results of the profiling process.
See the PHP Profile Perspective topic for more on the information displayed once a Profile session has been run.